Two potential causes of delayed development that have not been examined extensively include cerebral hypoxia and cerebrovascular instability -i.e., dysfunction of the brain’s homeostatic response that maintains stable cerebral blood flow during a change in posture.
Therefore, other potential causes of developmental delays must be identified. Moreover, large multicenter studies have excluded surgical factors as independent predictors of delays. Although advances in medical and surgical techniques have improved survival from CHD, those innovations have not produced dramatic improvements in neurodevelopmental outcomes. Infants with Congenital Heart Disease (CHD) are at high risk for developmental delays, with up to 75% experiencing delays in cognitive or motor development in pre-school to school-age years, and 65% requiring remedial academic or behavioral services. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Ĭompeting interests: The authors have declared that no competing interests exist. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ĭata Availability: All relevant data are within the Supporting Information files.įunding: NT received research grants from the Robert Wood Johnson Foundation University of California, Los Angeles, Sigma Theta Tau, Gamma Tau Chapter Children’s Hospital Los Angeles Clinical Services Research Grant and by grant UL1TR001855 from the National Center for Advancing Translational Science (NCATS) of the U.S. Received: SeptemAccepted: ApPublished: May 10, 2021Ĭopyright: © 2021 Tran et al. PLoS ONE 16(5):Įditor: Kazumichi Fujioka, Kobe University Graduate School of Medicine School of Medicine, JAPAN (2021) Cerebral oxygen saturation and cerebrovascular instability in newborn infants with congenital heart disease compared to healthy controls. Citation: Tran NN, Votava-Smith JK, Wood JC, Panigrahy A, Wee CP, Borzage M, et al.
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